| 摘要 |
<p>Atrial peptides comprising the amino acid sequence as follows: <CHEM> wherein R1 is absent, hydrogen, 5-aminopentanoic acid, 8-aminooctanoic acid, 7-aminoheptanoic acid, acetyl, Ser, SerSer, D-Arg, Arg, ArgSerSer or ArgArgSerSer; R2 is Cys, beta-mercaptopropionic acid or Pen; R3 is Phe, Cha, L-Tic, D-Tic or Nal; R4 is Gly, Pro, D-Ala or Ala; R5 is Gly, 6-aminocaproic acid, meta-aminomethylbenzoic acid, Pro, Ala or D-Ala; R6 is Arg, D-Arg, Orn, Lys or Gly; R7 is Ile, Leu, PropargylGly or Gly; R8 is Asp or Gly; R9 is D-Arg, Arg, Orn, Lys or Gly; R10 is Ile; R11 is Cys or Pen; R12 is OH, NH2, ChaArg, ProArg, PheArg, GlyArg, Arg,PheLys, (8-aminooctanoyl)Arg, AsnSer, SerPheArg or AsnSerPheArg; m is 0 or 1 and n is 0 or 1; or pharmaceutically acceptable salts, esters or amides thereof.</p> |
