Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides

摘要

Synthetic glycolipides having the general formula lipidyl-O-R wherein the lipidyl moiety is selected from the group consisting of 5-cholestene-3 beta -yl, ceramidyl, phosphatidylethanolamine and diacylglycerol and R represents a group having the formula <IMAGE> in which two symbols Z represent a glycopyranosyl rest and the other symbol Z a hydrogen atom or all three symbols Z represent a glycopyranosyl rest. These new glycolipides can be used for the solubilization of cholesterol in water or aqueous media, for the manufacture of lipide-vesicles or lipoproteins in which such a glycolipide is encapsulated as well as for the reduction of the cholesterol level in the blood plasma of mammals. Preferably the compound N-tris( beta -D-galactopyranosyloxymethyl)methyl-N alpha -(4-(5 cholesten-3 beta -yloxy)succinyl)glycinamide is used.