摘要 |
A 6-(1-acyl-1-hydroxymethyl) penicillanic acid deriv. of formula (I), its cationic salt when (I) contains COOH gp. and acid addn. salt when(I) contains basic N atom are new. In the formula, n is 0, 1 or 2; X is OH or OCOR2 (R2 is H or C1-4 alkyl); R is radical gp. forming ester, or acyloxymethyl or 1-(acyloxy) ethyl radical; R1 is e.g. C1-7 alkyl, C5-7 cycloalkyl, C6-12 cycloalkyl alkyl, C6-12 alkyl cycloalkyl, adamatyl, phenyl, C7-12 phenylalkyl, C7-12 alkylphenyl, C7-12 phenoxyalkyl, naphtyl, furyl, etc.. (I) are useful as antibacterials and β-lactamase inhibitors.
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