PARAMAGNETIC CHELATES

摘要

Compounds suitable for NMR imaging having the formula: (I) wherein a is 2 or 3; b is an integer from 0 to 4; Me(a+) is Fe(2+), Fe(3+), Gd(3+), or Mn(2+); E(b+) is an ion of an alkali metal, alkaline earth metal, alkyl ammonium, alkanol ammonium, polyhydroxyalkyl ammonium, or basic protonated amino acid, said ions representing a total charge of b; m is an integer from 1 to 5; R is H, alkyl with from 1 to 8 carbon atoms, alkyl with from 1 to 8 carbon atoms wherein from 1 to 5 carbons are substituted with OH; aralkyl with 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, hydroxyl, carboxyl, carboxamide, ester, SO3H, sulfonamide, lower alkyl, lower hydroxy alkyl, amino, acylamino; (poly)oxa-alkyl with 1 to 50 oxygen atoms and from 3 to 150 carbon atoms, wherein 1 to 5 hydrogen atoms may be substituted by OH; R1 is the same as R2 or is -CH2COOZ, -CH(CH3)COOZ, CH2CH2-N(CH2COOZ)2, a hydroxy arylalkyl, hydroxy pyridylalkyl, hydroxy aryl(carboxy)alkyl or hydroxy pyridyl-(carboxy)alkyl radical, where the aryl or pyridyl radical may be substituted by hydroxyl, hydroxy alkyl, alkyl, halogen, carboxyl or SO3H; R2 is -CH2COOZ, -CH(CH3)COOZ, wherein R3 is -CH2COOZ, -CH(CH3)COOZ or a monovalent radical having the structure X is a direct chemical bond, -O-, -S-, -NH-, n is the integer 2 or 3, with the proviso that when X represents a direct bond, n is 1, 2 or 3; Z is hydrogen or a unit of negative charge, and -(CH2)m- may also be -CH2-C(CH3)2-.