摘要 |
<p>This invention provides novel compounds of the formula (I): <CHEM> including all stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein, of A and B, one is C=O and the other is S @Y; R is hydrogen, hydroxy or methoxy; R1 is hydrogen or hydroxy; R2 is hydrogen or hydroxy; X is hydrogen, hydroxy or methoxy and Y is O or O2; provided that R and X do not both stand for methoxy. These compounds show potent growth inhibition activity against P-388 leukemia cells and are thereofore potentially useful in the treatment of cancer.</p> |