发明名称 Novel daunomycin and adriamycin sulfono and sulfoxo.
摘要 <p>This invention provides novel compounds of the formula (I): &lt;CHEM&gt; including all stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein, of A and B, one is C=O and the other is S @Y; R is hydrogen, hydroxy or methoxy; R1 is hydrogen or hydroxy; R2 is hydrogen or hydroxy; X is hydrogen, hydroxy or methoxy and Y is O or O2; provided that R and X do not both stand for methoxy. These compounds show potent growth inhibition activity against P-388 leukemia cells and are thereofore potentially useful in the treatment of cancer.</p>
申请公布号 EP0269339(A2) 申请公布日期 1988.06.01
申请号 EP19870310102 申请日期 1987.11.16
申请人 ABI BIOTECHNOLOGY INC. 发明人 WONG, CHIU MING
分类号 A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;C07H15/252;(IPC1-7):C07H15/252 主分类号 A61K31/70
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