Pharmacologically active tripeptides and process for their synthesis

摘要

Pharmacologically active tripeptides, with at least a retro-inverted peptidic bond, definable by means of the following general formulae: <IMAGE> Ia <IMAGE> Ib <IMAGE> Ic their pharmaceutically acceptable salts, esters or alkyl amides, wherein R1 represents a hydrogen atom, an alkyl group with a maximum of 7 carbon atoms, an aryl, hydroxyalkyl or hydroxyarylalkyl, guanidylalkyl, amino-alkyl, alkyl-oxy-alkyl, acylamino-alkyl, imidazolylalkyl, indolyl-alkyl, mercapto alkyl, alkylmercaptoalkyl, carbamoyl-alkyl, carboxyalkyl, alkyl-carbamoylalkyl or alkyloxy-carbonylalkyl group; R2 represents a <IMAGE> group, Z is an OH, OR3, NH2, NHR3 group, wherein R3 represents an alkyl group with a number of carbon atoms comprised within the range of from 1 to 10.