发明名称 PROCESS FPR PREPARING OXAZOLE DERIVATIVES
摘要 Calcium oxaprozin is prepared by treating oxaprozine with calcium ion supplier. β-(4,5-diphenyloxazol-2-il) propionic acid (6kg) is stirred in distilled water (60kg) and 46-48% sodium hydroxide solution (1.85kg) to transfer sodium salt. In this solution, add calcium chloride solution and filter the produced salt in vacuum and wash with distilled water until chloride is absent. The product is β-(4,5-diphenyloxazol-2-il) propionic acid 4H2O.
申请公布号 KR880000871(B1) 申请公布日期 1988.05.28
申请号 KR19820001829 申请日期 1982.04.26
申请人 JOHN WYETH & BROTHER LTD. 发明人 MUGHAL AHMED S.
分类号 C07D263/56;A61K31/42;A61K31/421;A61K31/423;A61P29/00;C07D263/32 主分类号 C07D263/56
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