| 摘要 |
NEW MATERIAL:A phenyl(or phenylamino)alkylamine derivative shown by formula I (R<1> is H, halogen or lower, alkyl; R<2> is group shown by formula II, group shown by formula III, etc.; R<3> and R<4> are H or lower alkyl with the proviso that R<3> and R<4> may be bonded to form morpholine ring or piperidine ring; a is methine group or N; B is lower alkylene; R<5> and R<6> are H, alkyl, pyridyl, thienyl, etc.; R<7> is H, lower alkyl or phenyl) or a salt thereof. EXAMPLE:2-{[N-3-Dimethylamino)propyl-N-phenyl]amino}-5-hexyl-4-methylt hiaz ole.fumarate. USE:Useful as a preventive and remedy for gastric diseases, such as inhibitor of secretion of acid in the stomach, preventive and remedy for gastric ulcer, etc., being orally or parenterally administered. PREPARATION:For example, a compound shown by formula IV is reacted with a haloketone shown by formula V is a solvent such as methanol, etc., under heating to give a compound shown by formula I.
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