| 摘要 |
NEW MATERIAL:The amino-substituted acetonitrile derivative of formula I [A is group of formula II, and III (R1 is H, alkyl, halogen, alkoxy, methylthio, nitro, cyano, etc.; n and m are 0-4), formula IV (R2 is H, alkyl, phenyl or pyridyl), formula V, formula VI, etc.; Y is W are H, alkyl, acetyl or benzyl; B is MR3 (M is O or S; R3 is alkyl, propargyl, alkoxy, etc.), formula VII, formula VIII, etc.]. EXAMPLE:2-Nicotinylamino-2-isopropoxyacetonitrile. USE:A fungicide for agricultural and horticultural use. PREPARATION:The compound of formula I can be produced by reacting an amide derivative of formula A-CON(Y)H with an alpha-ketocarboxylic acid ester of formula O=C(W)-COOR4, chlorinating the OH group of the resultant compound of formula IX, reacting the product with a compound of formula BZ (Z is H or alkali metal) and amidating and dehydrating the obtained compound of formula X.
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