LABELLING OF ORGANIC MOLECULES

摘要

A process for isotopically labelling certain chemical compounds, with a selected or desired isotopic label comprising first treating a precursor material with the isotopic material to exchange the hydrogen atoms of the precursor material with the isotopic material and then or simultaneously reacting the exchanged precursor with a chemical compound so as to label the chemical compound with the isotopic material at a desired preselected location within the molecule of the chemical compound. A typical example involves first forming deuterated Raney nickel and then reacting the deuterated Raney nickel with an organic compound under relatively mild conditions so that specific selective hydrogen-deuterium exchange occurs within the molecules of the chemical compound at a pre-selected location within the molecule.