NUCLEIC ACID FOR PRODUCING NOVEL DAF COMPOSITION AND PRODUCTION OF SAID DAF COMPOSITION

摘要

Methods and host-vector systems are provided for the recombinant expression of native DAF and its amino acid sequence and glycosylation variants. The DAF may be mDAF which can bind to membranes or sDAF which has a novel amino acid sequence at the C-terminal end eliminating the membrane binding region, so that it is secreted into the blood in a biologically active form. Native DAF or its variants are formulated into therapeutic compositions for immunomodulatory effects or diagnostic preparations for the assay of DAF and its antibodies.