发明名称 |
COMBINATIONS OF TUMOR NECROSIS FACTORS AND ANTI-INFLAMMATORY AGENTS AND METHODS FOR TREATING MALIGNANT AND NON-MALIGNANT DISEASES |
摘要 |
Combinations and methods for the treatment of malignant and non-malignant diseases. More particularly, this invention relates to combinations of natural or recombinant tumor necrosis factors (''TNF'') and non-steroidal anti-inflammatory agents, such as indomethacin and ibuprofen, useful for the growth inhibition or killing of transformed cells. According to this invention, the non-steroidal anti-inflammatory agents are used to reduce or eliminate the toxic side effects of high doses of TNFs employed in the treatment of malignant and non-malignant neoplastic diseases. Advantageously, the combinations and methods of this invention allow the administration of higher doses of TNF than those tolerated in conventional treatment regimens based upon TNF alone. |
申请公布号 |
WO8802632(A1) |
申请公布日期 |
1988.04.21 |
申请号 |
WO1987US02602 |
申请日期 |
1987.10.14 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;BIOGEN N.V. |
发明人 |
GOLDBERG, ALFRED, L.;FIERS, WALTER, C.;KETTELHUT, ISIS, C. |
分类号 |
A61K38/00;A61K38/19;A61K45/06;A61P29/00;A61P35/00;(IPC1-7):A61K37/02;C07K15/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|