发明名称 |
PENETRATION ENHANCERS FOR TRANSDERMAL DELIVERY OF SYSTEMIC AGENTS |
摘要 |
Method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having structural formula (I), wherein X may represent sulfur or two hydrogen atoms; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-18 and R is -CH3, or a compound of formula (II) or (III), wherein R'' is H or halogen. |
申请公布号 |
WO8802626(A1) |
申请公布日期 |
1988.04.21 |
申请号 |
WO1987US02582 |
申请日期 |
1987.10.07 |
申请人 |
NELSON RESEARCH AND DEVELOPMENT COMPANY |
发明人 |
MINASKANIAN, GEVORK;PECK, JAMES, V. |
分类号 |
C07D223/04;A61K47/22;C07D211/06;C07D223/06;C07D225/02;(IPC1-7):A61K31/445;A61K31/33;A61K31/55;A61K31/70;A61K31/56;A61K31/505;A61K31/34;A61K31/04;A61K31/415;A61K31/075;A61K31/40;A61K31/44 |
主分类号 |
C07D223/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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