PHENYLNONATETRAENIC-ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

1. Compounds of the formula see diagramm : EP0169571,P20,F2 wherein R1 signifies hydrogen, lower alkyl, chlorine, fluorine or trifluoromethyl ; R2 signifies hydrogen, lower alkoxy, trifluoromethyl-lower alkoxy, hydroxy, lower alkyl, chlorine, trifluoromethyl or fluorine ; R3 signifies hydrogen, lower alkyl, chlorine or fluorine ; R4 signifies alkyl with 4-10 C-atoms or -CH2 (CH2 )n CH2 OH ; X signifies -CH(R10 )O-, -CH(R10 )-, -O-, -C(R10 ) = CH- or -N(R10 )-; R5 signifies COOR9 ; n signifies 6 or 7 ; and R7 , R8 , R9 and R10 signify lower alkyl or hydrogen and salts thereof when R9 is hydrogen.