| 摘要 |
NEW MATERIAL:The compound of formula I (R1 is H or alkyl; R2 is alkyl, alkenyl, alkynyl, aralkynyl, alkyloxy or aryloxy; R3 and R4 are H or OH- protecting group; R5 is alkyl, alkynyl or cycloalkyl which may be substituted with hetero-ring; the wavy line represents R-configuration, S-configuration of their mixture) or its salt. EXAMPLE:4-[7-Hydroxy-6-(3-hydroxy-1-octenyl)-1-methyl-2-azabicyclo[3,3 ,0]oct-2- en-3-yl]thiobutanoic acid. USE:An antithrombotic agent and antiulcer agent. PREPARATION:The compound of formula I can be produced by converting the lactam of formula III derived from the compound of formula II into the thiolactam of formula IV and alkylating the product with an alkyl halide in a solvent in the presence of a base. |
