AZAINDOLE AND INDOLIZINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS

摘要

Compounds of formula (I), wherein: either one Y is -N- and the remainder are -CH-; X is a compound of formula (II); X<1> is a compound of formula (III), with appropriate bond formation; R1 is a primary or secondary alkyl, free of asymmetric carbon atoms; R2 is a substituted or unsubstituted phenyl, primary or secondary C1-6 alkyl, free of asymmetric carbon atoms, C3-6 cycloalkyl or phenylalkyl as defined in the specification; A is a) a compound of formula (IV) or (V), b) -(CH2)n-, wherein n is 1, 2 or 3; Z is a) a compound of formula (VI), b) a compound of formula (VII), in which R8 is hydrogen, R9 or M, wherein R9 is a physiologically acceptable and hydrolysable ester group, and M is a pharmaceutically acceptable cation; or: each Y is -CH-, X is -N-, X<1> is a compound of formula (VIII), with appropriate bond formation; R1 and R2 are independently as defined under R2 above and R2 may additionally be hydrogen; A and Z are as defined above. Said compounds are obtained by multi-step processes and are useful as hypolipoproteinemic and anti-atherosclerotic agents.