发明名称 |
Monoclonal antibodies specific to surface receptor for IgE and hybrid cell lines producing these antibodies and use thereof. |
摘要 |
<p>An object of the present application is to provide new anti-Fc epsilon R-antibodies which enable B cells to be identified at a specific differentiation stage as well enabling the different degrees of atopy and Fc epsilon -receptor expression to be defined as a result by the showing that Fc epsilon R is a B cell specific phenotype marker, the expression of which is strictly correlated with the differentiation stage of B cells, especially with the isotype switching in B cells. Therefore, Fc epsilon R positive B cells can be recognized by detection with the new antibodies of the expressed Fc epsilon R, e.g. the expressed Fc epsilon R in supernatant or biological fluid having a molecular weight of about 25 Kd, and the use thereof in an ELISA. An further object are hybrid cell lines producing these antibodies.</p> |
申请公布号 |
EP0259585(A1) |
申请公布日期 |
1988.03.16 |
申请号 |
EP19870110658 |
申请日期 |
1987.07.23 |
申请人 |
KISHIMOTO, TADAMITSU, PROF. |
发明人 |
KISHIMOTO, TADAMITSU, PROF. DR.;SUEMURA, MASAKI, DR.;KIKUTANI, HITOSHI, DR.;BARSUMIAN, EDWARD L., DR. |
分类号 |
G01N33/53;A61K39/395;C07K14/005;C07K14/195;C07K14/705;C07K16/00;C07K16/28;C07K19/00;C12N15/02;C12P21/00;C12P21/08;C12R1/91;G01N33/566;G01N33/569;G01N33/577;(IPC1-7):C12P21/00;C12N15/00;C12N5/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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