MONOCLONAL ANTIBODIES TO FIBRIN

摘要

Monoclonal antibodies specific for fibrin, its plasma precursor fibrinogen and their plasmin derived degradation products. Monoclonal antibodies capable of reacting with fibrin, fibrinogen and their degradation products are of value for the diagnosis and treatment of vascular disorders, such as thrombosis and disseminated intravascular coagulation. The monoclonal antibodies of this invention possess distinctive characteristics and capabilities which make them suitable for in vitro clinical diagnostic purposes, such as their ability to distinguish between fibrinogen and fibrin and their derivatives. Moreover, the monoclonal antibodies of this invention allow the accurate measurement of the in vivo concentration of these blood proteins.