Peptides or proteins which belong to a melanoma-associated antigen are described. These are prepared in large amounts using recombinant DNA techniques and/or chemical synthetic methods. The peptides or proteins can be used as immunogens in vaccine formulations which elicit an immune response able selectively to destroy melanoma cells in a vaccinated individual. When the peptides or proteins are expressed by a recombinant virus, it is possible to prepare vaccine formulations based on inactivated viruses or based on live viruses.
申请公布号
DE3703702(A1)
申请公布日期
1988.02.18
申请号
DE19873703702
申请日期
1987.02.06
申请人
ONCOGEN,SEATTLE
发明人
P. BROWN,JOSEPH;D. PLOWMAN,GREGORY;E. HELLSTROM,KARL;F. PURCHIO,ANTHONY;PENNATHUR,SRIDHAR;D. ESTIN,CHARLES;M. ROSE,TIMOTHY;HELLSTROM,INGEGERD;HU,SHIU-LOK