| 摘要 |
<p>NEW MATERIAL:The compound of formula I {A is group of formula II (B is alkylene) or CO; R<1> and R<2> are alkyl, phenylalkyl or together with bonding N form the group of formula III [R<3> is (substituted) phenyl; Z is CO, group of formula IV or -B-CR<5>H- (R<4> is OH, alkanoyloxy, etc.; R<5> is CN, halogen, etc.)]}. EXAMPLE:6-[4-( 3-Phenyl-3-hydroxyiminopropyl )-1-piperazinylcarbonyl]-3,4-dihy drocarbostyryl. USE:It has excellent positively inotropic action, coronary blood flow increasing action and hypotensive action, is almost free from increment of pulse rate and has low central side effects. PREPARATION:A compound of formula I wherein A is CO can be produced by the amide bond-forming reaction of a carbostyryl derivative of formula V or its carboxyl-activated derivative with an amine of formula HNR<1>R<2>.</p> |
