发明名称 |
LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE |
摘要 |
A liposome composition designed for enhanced binding to mucosal tissue. The liposomes contain about 10-40 mole percent of an amine-derivatized lipid component in which a charged amine group is spaced from a lipid polar head region by a carbon-containing spacer arm at least 3 atoms in length. The liposomes preferably have a close packed lipid structure produced by inclusion of between of between 20-50 mole percent of cholesterol or an amine-derivatized cholesterol, and/or phospholipids with predominantly saturated acyl chain moieties. For ophthalmic use, the liposomes may be suspended in an aqueous medium containing a high-viscosity polymer, to enhance further the retention of liposomes on a corneal surface. |
申请公布号 |
WO8800824(A1) |
申请公布日期 |
1988.02.11 |
申请号 |
WO1987US01833 |
申请日期 |
1987.07.28 |
申请人 |
LIPOSOME TECHNOLOGY INC. |
发明人 |
GUO, LUKE, S., S.;REDEMANN, CARL, T.;RADHAKRISHNAN, RAMACHANDRAN |
分类号 |
A61K9/127;(IPC1-7):A61K9/52;B01J13/02;A61K9/66 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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