HIGH LEVEL INDUCIBLE EXPRESSION OF HETEROLOGOUS GENES

摘要

A method for producing high level expression of a selected protein and stable cell lines useful therein. This method involves culturing a cell line containing amplified copies of a cDNA sequence encoding a steroid or other ligand receptor, and amplified copies of a vector comprising an expression control sequence (incuding a promoter) which is responsive to the complex of said ligand and its receptor in operative association with a selected exogenous protein, in the presence of the ligand.