| 摘要 |
Substituted pyrido[2,3-b]-1,4-benzodiazepin-6-ones of the formula I …<IMAGE>… in which… R<1> denotes an alkyl group having 1 to 4 C atoms, a chlorine atom or a hydrogen atom;… R<2> represents a hydrogen atom or a methyl group;… R<3> and R<4> each denote a hydrogen atom, a fluorine, chlorine or bromine atom or an alkyl group having 1 to 4 C atoms, but with the proviso that at least one of the radicals R<1>, R<2>, R<3> and R<4> is different from hydrogen,… R<5> and R<6> represent alkyl radicals having up to 6 carbon atoms and which are identical or different from one another or together with the nitrogen atom between them form a 4- to 7-membered, saturated, monocyclic, heteroaliphatic ring which can optionally be interrupted by an oxygen atom or by the N-CH3 group,… Z is either a single bond or an oxygen atom, or a methylene or 1,2- ethylene group… and… A is a methylene group in position 2 or 3 of the heteroaliphatic ring, or when linked in position 3 is also a single bond, and their salts with inorganic or organic acids are described. …<??>The compounds of the formula I have favourable effects on the heart rate and are suitable for use in human and veterinary medicine as vagal pacemakers for the treatment of bradycardias and bradyarrhythmias in view of a lack of gastric acid secretion- inhibiting, salivation-inhibiting and mydriatic effects, as well as excellent absorption. |
