发明名称 |
Efficient stereoconservative syntheses of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines and intermediates therein. |
摘要 |
<p>Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity <CHEM> wherein R<1> is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH2)m Ph wherein m is O-3 and Ph is a substituted or unsubstituted phenyl group including l) O,N-dialkylation, directly or stepwise of (R)- or (S)-proline 2) aminolysis 3) reduction to formation of the (R)- or (S)-isomer of the compound of the formula I, and new intermediates II and III in optical active form obtained by the reaction steps above and wherein R<2> is defined as R<1> above. <CHEM> h</p> |
申请公布号 |
EP0253785(A1) |
申请公布日期 |
1988.01.20 |
申请号 |
EP19870850165 |
申请日期 |
1987.05.19 |
申请人 |
ASTRA LAKEMEDEL AKTIEBOLAG |
发明人 |
FEDERSEL, HANS-JURGEN;HOGBERG, THOMAS;RAMSBY, STEN INGVAR;STROM, HANS ERIC PETER |
分类号 |
C07D207/00;C07B53/00;C07D207/08;C07D207/09;C07D207/16 |
主分类号 |
C07D207/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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