| 摘要 |
PURPOSE:To obtain a compound useful as a drug having antipsychotic action and antianxiety action, by catalytically reducing an unsaturated imide derivative. CONSTITUTION:An unsaturated imide derivative shown by formula I (group shown by formula II is formula III, etc.; Y is CH=CH or CidenticalC; R is phenyl-1- pyridyl, 1,2-benzo-3-isothiazolyl, etc.) is hydrogenated in the presence of a cata lyst (e.g. Pd-C) in a solvent such as THF, etc., to give the aimed substance shown by formula IV(group shown by formula V is group shown by formula III, etc.). Acid addition salts of various acids can be optionally formed and formed into a basic form by alkali treatment. The compound shown by formula I is obtained by reacting an imide derivative with piperazine derivative in the presence of an acid binder. |
