CL-1957A ANTIBIOTIC COMPOUND AND ITS PRODUCTION

摘要

A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957A which also exhibits antitumor properties. The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound. The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.