| 摘要 |
The invention concerns angiotensin- converting enzyme (ACE) inhibitors of the formula I <IMAGE> wherein RA and RB are radicals of the formula <IMAGE> respectively, in which Ro is carboxy or a functionally modified carboxy; R1 is hydrogen, lower alkyl, amino(lower) alkyl, aryl, aryl (lower) alkyl, cycloalkyl or cycloalkyl (lower) alkyl; R2 is hydrogen or lower alkyl; R3 and R4, each independently, represent hydrogen, lower alkyl, lower alkoxy, lower alkanoyloxy, hydroxy, halogen, trifluoromethyl, or R3 and R4 taken together represent lower alkylenedioxy; R5 is hydrogen or lower alkyl, and X represents oxo, two hydrogens, or one hydroxy together with one hydrogen; and wherein the carbocyclic ring may also be hexahydro or 6,7,8,9- tetrahydro; salts and complexes thereof; and stereoisomers of all these compounds. They are prepared, for example, by reducing a compound corresponding to the formula I, having an additional double bond located at the carbon atom in 3-position. |
