| 摘要 |
<p>The invention relates to compounds of formula (I), physiologically acceptable salts thereof, formulations containing them, their preparation and their use in medicine. In formula (I) <CHEM> Q and Q<1>-Q<8> are independently selected hydrogen and C1-4 alkyl; A is a group of formula -(CO)k-(NQ<9>)m-(CH2)n- where k and m are either both 0 or both 1, n is from 1 to 6, Q<9> is selected from hydrogen and C1-4 alkyl and any of the -(CH2)n- groups independently are optionally substituted by one or two C1-4 alkyl groups; B is a C1-6 alkyl group; E and Z are independently selected from carboxy derivatives thereof; D is hydrogen or a C1-6 alkyl group which is optionally substituted by an amino group; (X) is a benzene ring or a naphthyl or indolyl ring system any of which is optionally substituted in any position by one or more substituents independently selected from C1-4 (itself optionally substituted by one or more halogen atoms (C1-4 alkoxy, halo, nitro, amino, carboxy, C1-4 alkoxycarbonyl and hydroxy; and -N Y is a pyrrolidinyl, oxazolidinyl or thiazolidinyl ring, or a ring system selected from indolinyl, quinolinyl and tetrahydroquinolinyl.</p> |
