| 摘要 |
The multilayered composite wound dressing comprises of a semipermeable membrane, a permeable supporting and reinforcing layer, and a non-stick, self-sealing biodegradable tissue interface. The semipermeable membrane may be a synthetic collagen, an alginate or a biocompatible polymer and it controls the rate of water vapour transmission from the wound surface. The permeable supporting and reinforcing layer provides mechanical strength and is usually a textile fabric which may also be made electrically conductive by coating it with a carbon-doped silicon or natural rubber or depositing metal on the fabric. Alternatively, an activated carbon cloth fabric can also be used. The biodegradable tissue interface may be synthetic collagen, sodium-calcium alginate or collagen-alginate complex, and it provides non-stick haemostatic sealing and aids the wound repair processes. For topical medication, growth promoting, antibacterial, anti-allergic and therapeutic agents may also be incorporated. Any combination of each of the materials suitable for a particular layer can be used for a specific application. The conductive supporting and reinforcing layer can be used to provide electrical charge transfer and stimulation of the wound using external fields which has been shown to enhance the wound healing process, produce post-operative pain relief and bacterial-inhibition. The composite wound dressing has application inter alia in treating general surgical wounds, burns, bedsores, infected ulcers, donor sites for skin grafts or alternatively can be used for electrode dressing in transcutaneous and functional stimulation. |
