COMPOSITION AND METHOD FOR TREATING A THROMBUS AND EMBOLUS

摘要

Composition which provides a synergistic action in dissolving blood clots and reestablishing and maintaining blood flow through a thrombosed coronary vessel or other blood vessel. The clot-dissolving composition of the present invention is a solution containing an effective concentration of a proteolytic enzyme and an effective concentration of a surface active copolymer. The surface active copolymer is preferably an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of about 950 to 4000 and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes from about 50 % to 90 % by weight of the compound. The proteolytic enzymes that can be used in the clot-dissolving composition of the present invention include, but are not limited to, streptokinase, urokinase, and tissue plasminogen activator.