LIPOPOLYSACCHARIDE AND NATURAL FACTOR COMPOSITIONS FOR ANTI-TUMOR THERAPY AND METHOD OF TREATMENT

摘要

Bacterial lipopolysaccharide (LPS) can be used to induce release of factors into the serum enabling rejection of tumors and increasing the efficacy of added anti-tumor agents. Thus exogenous TNF, when used together with LPS or other factors induced by LPS can be used at lower non-toxic doses to cause tumor rejection. These factors can be combined in anti-tumor therapy with other chemotherapeutic agents such as indomethacin or cyclophosphamide or natural agents such as platelet factor 4 which block negative feedback responses suppressing the immune system, thereby mediating the body resistance to the therapy.