Purine and pyrimidine compounds and their use as anti-viral agents.

摘要

A 9-substituted-purine or 1-substituted-pyrimidine compound of the formula Z-CH2-O-CH(CH2OR')-CH2OR I wherein Z represents a uracil, 5-fluorouracil, cytosine, 5-azacytosine or N<2>-acetylguanine group; and R and R' @are independently selected from H, silyl, substituted silyl, C1-6 alkyl and phenyl(C1-6 alkyl); or a pharmaceutically-acceptable salt thereof. Such compounds are useful for the treatment of viral infenctions in live mammalian cells.