| 摘要 |
Benzothiazinone derivatives I <IMAGE> (I) with R1 and R4 being H, alkyl, alkoxy, Hal, CF3, NO2, OH, acetamido or amino, R2 being H, (cyclo)alk(en)yl, cycloalkylakyl, phenyl or phenylalkyl, A being (CH2)mO(CH2)n, (CH2)p-CH(OH)-CH2)q, (CH2)p-CH(OCH3)-(CH2)q, or (CH2)rOCH2-CO- and (CH2)s-CO-, R5 being NR(6)R(7) or certain cyclic amines, show a calcium-antagonistic action. They are obtained, inter alia, from II <IMAGE> (II) by reaction with III <IMAGE> IIIa <IMAGE> IIIb <IMAGE> IIIc <IMAGE> IIId <IMAGE> IIIe A and B are same or different and are lower alkylene having 1 to 6 carbon atoms; and n is 3 to 4. |
