| 摘要 |
NEW MATERIAL:A compound expressed by the formula OCN-R-X [R is alkylene expressed by the formula (CH2)m (m is an integer of 1-8) or ether bond- containing alkylene expressed by the formula (n and p are integers of 1-4); X is silyl expressed by the formula SiR<1>R<2>R<3> are 1-8C alkyl, alkenyl, etc.; R<3> is 1-8C alkyl, aryl, etc.)]. EXAMPLE:3-Isocyanatopropyldimethylethenylsilane. USE:A raw material and synthetic intermediate for producing medicines, e.g. 5-fluorouracil derivatives, etc., useful as a carcinostatic agent. PREPARATION:A carboxylic acid expressed by the formula HO2C-R-X which is a starting raw material is first reacted with diphenylphosphoric acid azide in the presence of triethylamine in a solvent, e.g. THF, etc., and the resultant acid azide expressed by the formula N3CO-R-X is then subjected to the Curtius rearrangement to afford the aimed compound.
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