| 摘要 |
PURPOSE:To obtain a novel dentifrice having antimycotic activity, especially preventive effect against oral candidiasis, by adding an antibacterial substance produced by yeast, especially an anti-yeast substance (i.e. killer protein) to a dentifrice composition. CONSTITUTION:The objective dentifrice can be produced by adding an antibacterial substance produced by yeast, especially an anti-yeast substance (killer protein) produced by Hansenula mrakii or Hansenula anomala at an amount of about 1-100mug/ml to a dentifrice composition composed of a powdery component, a wetting agent, a surfactant, a binder, a perfume and a sweetener and optionally added with other particular components.
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