发明名称 |
4-morpholinyl-1H-indoles, pharmaceutical compositions and use |
摘要 |
Novel racemic mixtures and optical isomers of 4-morpholinyl-1H-indoles of the formula: <IMAGE> 1 wherein R and R1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R2 is selected from the group consisting of hydroxymethyl, alkylthiomethyl of 1 to 3 alkyl carbons, cyanomethyl and carboxy optionally esterified with an aliphatic alcohol of 1 to 5 carbon atoms or optionally amidified with an amine of the formula <IMAGE> R3 is alkyl of 1 to 4 carbon atoms and R4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having the ability to activate neurons and to protect the same against ischemic or anoxic aggressions.
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申请公布号 |
US4699907(A) |
申请公布日期 |
1987.10.13 |
申请号 |
US19860941037 |
申请日期 |
1986.12.12 |
申请人 |
ROUSSEL UCLAF |
发明人 |
GASC, JEAN-CLAUDE;NEDELEC, LUCIEN;RETTIEN, CLAUDE;NANOPOULOS, DINAH W. |
分类号 |
A61K31/535;A61P9/12;A61P25/28;C07D209/08;C07D413/04;(IPC1-7):A61K31/535;C07D413/02 |
主分类号 |
A61K31/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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