| 摘要 |
An enantioselective process for the preparation of homoallyl alcohol enantiomer of formula II <CHEM> wherein: X<1>, X<2> and X<3> are independently chosen from the group consisting of hydrogen, chlorine, bromine, fluorine, iodine, C1 to C6 alkyl, C1 to C6 haloalkyl, and haloaryl; and R<1>, R<2>, R<3> and R<4> are independently chosen from the group consisting of hydrogen, halogen, alkyl, alkenyl, alkynyl, benzyl, substituted benzyl, phenyl, substituted phenyl; or R<3> and R<4> is as hereinbefore defined and R<1> and R<2> form a carbocyclic or heterocyclic ring; which process comprises; reacting an aldehyde of formula III with an alkene of formula IV in the presence of an optically-active organometallic catalyst. <CHEM> Furthermore, the compound of formula II can be isomerised to the allylic alcohol of formula I with retention of optical purity. <CHEM> n |
