发明名称 HYDROCORTISONE-17-CARBOXYLIC-ACID ESTER 21-THIOCARBOXYLYC-ACID ESTERS, THEIR PREPARATION AND THEIR USE AS MEDICINES
摘要 1. Claims (for the Contracting States : BE, CH, DE, GB, IT, LI, LU, NL, SE) 3,20-dione 11 beta-hydroxy-pregn-4-ene S-21 thioacetate-17-butyrate. 1. Claims (for the Contracting State : AT) Process for the preparation of 3,20-dione 11 beta-hydroxy-pregn-4-ene S-21-thioacetate-17-butyrate and 3,20-dione 11 beta-hydroxy-pregn-4-ene S-21-thiopropionate-17-butyrate, characterized in that it comprises reacting a 21-sulphonate steroid of formula : see diagramm : EP0141684,P9,F2 in which R is a lower alkyl with an alkali metal thiocarboxylate of formula : M-S-CO-R1 in which M is an alkali metal atom and R1 methyl or ethyl.
申请公布号 EP0141684(B1) 申请公布日期 1987.09.30
申请号 EP19840401553 申请日期 1984.07.24
申请人 JOUVEINAL S.A. 发明人 AUBARD, GILBERT GUSTAVE;GROUHEL, AGNES GENEVIEVE;JUNIEN, JEAN-LOUIS;ROUX, CLAUDE PAUL JOSEPH;TOROSSIAN, DIERAN ROBERT
分类号 A61K31/57;C07J5/00;A61P29/00;C07J31/00;(IPC1-7):C07J31/00 主分类号 A61K31/57
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