摘要 |
NEW MATERIAL:The compound of formula I (R<1> and R<2> are lower alkyl, hydrox yl, lower alkoxy, phenyl, phenyloxy, etc.; R<3> and R<4> are H, lower alkyl, phenyl, phenyl-lower alkyl, etc,; Y is O or S) or its salt. EXAMPLE:N-(dibenzylphosphoryl)glutathione dibenzyl ester. USE:A remedy for hepatic diseases. PREPARATION:The compound of formula I can be produced e.g. by reacting an oxidized glutathione derivative of formula II (e.g. oxidized glutathione tetrabenzyl ester) with a phosphoric acid halide compound of formula III (X is halogen) (e.g. dibenzylphosphoric acid chloride) and reducing the reaction product with tri-n-butylphosphine. |