| 摘要 |
<p>PURPOSE:To produce the titled substance useful as a synthetic intermediate of beta-lactam antibiotic substances, in high yield, by carrying out the photo-sensitized reaction of a 2,2-dimethylthiazolidine derivative in an aprotic solvent at a low temperature, and reducing the product without separating from the reaction system. CONSTITUTION:The titled compound can be produced by (1) carrying out the photo-sensitized reaction of the 2,2-dimethylthiazolidine derivative of formula I (R<1> is H or lower alkyl; R<2> is amino-protecting group) in an aprotic solvent such as benzene, tetrahydrofuran, etc. at a low temperature, preferably at -20- 0 deg.C, in the presence of a photo-sensitizer such as methylene blue, thionine, etc. to obtain 2,2-dimethyl-5-hydroperoxythiazolidine derivative of formula II (a novel compound), and (2) directly reducing the 5-hydroperoxy group of the compound in the presence of a reducing agent. The reduction proceeds easily at room temperature.</p> |
