NOVEL THIOPEPTOLIDE SUBSTRATES FOR VERTEBRATE COLLAGENASE

摘要

The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences: R-Pro-X-Gly-S-Y-Z-Gly-R1 wherein R=H or N-protecting group, X=Leu, Ile, Phe, Val, Gln, Ala, Y=Leu, Ile, Phe, Val, Ala, Z=Leu, Ile, Phe, Val, Gln, Ala, and R1=terminal amide, carboxyl or ester group.