Cephalosporin deoxygenation process

摘要

A process for the preparation of 7 beta -acylamino-3-substituted-3-cephem-4-carboxylic acid compounds comprising reacting at -70 DEG C. to 0 DEG C. in an inert organic solvent phosphorus pentachloride with a cephalosporin compound in the presence of an olefinic compound having at least one carbon-carbon double bond having not more than three hydrogen atoms attached thereto capable of removing chlorine at least in part by addition to a carbon-carbon double bond.