发明名称 CYCLOPHOSPHAZENE COMPOUNDS
摘要 1. Claims for the Contracting States : AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds having the formula I : see diagramm : EP0240392,P18,F1 in which : Az is a 1-aziridinyl radical, substituted or non-substituted, the substitution consisting of 1 to 4 C1 to C3 alkyl or alkoxy radicals, A, B and C, independently of one another, can represent an alkylene or alkenylene or alkynylene chain which may be straight or branched, substituted or non-substituted, and can be interrupted by one or more divalent radicals -NR3 -, -S- or -O-, and R1 , R2 and R3 , independently of one another, can represent a hydrogen atom or a substituted or non-substituted alkyl radical or a substituted or non-substituted alkenyl radical or a substituted or non-substituted alkynyl radical or a substituted or non-substituted aryl radical, and the substitutions of the -A-, -B- and -C- chains and the radicals R1 , R2 and R3 are chosen from among one or more halogen atoms or imino, amino or aryl radicals, non-substituted or substituted by one or more halogen atoms or C1 to C3 alkyl radicals. 1. Claims for the Contracting States : ES, GR A method of preparing a compound having the formula I : see diagramm : EP0240392,P20,F1 in which : Az is a 1-aziridinyl radical, substituted or non-substituted, the substitution consisting of 1 to 4 C1 to C3 alkyl or alkoxy radicals, A, B and C, independently of one another, can represent an alkylene or alkenylene or alkynylene chain which may be straight or branched, substituted or non-substituted, and can be interrupted by one or more divalent radicals -NR3 -, -S- or -O-, and R1 , R2 and R3 , independently of one another, can represent a hydrogen atom or a substituted or non-substituted alkyl radical or a substituted or non-substituted alkenyl radical or a substituted or non-substituted alkynyl radical or a substituted or non-substituted aryl radical, and the substitutions of the -A-, -B- and -C- chains and the radicals R1 , R2 and R3 are chosen from among one or more halogen atoms or imino, amino or aryl radicals, non-substituted or substituted by one or more halogen atoms or C1 to C3 alkyl radicals, characterised in that : a) a substituted or non-substituted polyamine having the formula II : H(R1 N)-A-NH-B-NH-C-(NR2 )H is reacted with an excess of the dichlorinated gem compound having the formula III : see diagramm : EP0240392,P21,F1 or b) an excess of the aziridine, substituted or non-substituted, is reacted with the compound having the formula IV : see diagramm : EP0240392,P21,F2
申请公布号 AU6968287(A) 申请公布日期 1987.09.10
申请号 AU19870069682 申请日期 1987.03.04
申请人 PF MEDICAMENT 发明人 LABARRE JEAN-FRANCOIS;SOURNIES FRANCOIS
分类号 A61K31/675;A61P35/00;A61P37/00;C07F9/6593 主分类号 A61K31/675
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