| 摘要 |
A conjugate compound has the structure: …<CHEM>… wherein… R<1> is -(CH2)p-R<6>-(CH2)q- where p and q are the same or different and are 0, 1 or 2 and -R<6>- is -(CH2)n-, where n is 0 or 1,-NH-, -O-, -S- or , R<1> optionally being alkyl substituted, provided that neither p nor q is O or unless R<6> is -CH2-,… R<2> are -CH2CN2- or -CH2CH2CH2-, optionally alkyl, alkoxyalkyl or hydroxyalkyl substituted,… R<3> are the same or different and are -H, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, carboxyalkyl ester, phosphate, sulphonate or phosphonate… R<4> is …<CHEM>… optionally alkyl substituted, wherein R7 iS -H, alkyl, hydroxyalkyl, or alkoxyalkyl provided that when R<4> is -CH @H-CH2-,…… R<3> is not carboxyalkyl,… R<5> is a linker, and… Ab is an antibody. …<??>The conjugate compound provides for complexes of metals such as Tc, Co, Re, Cu, Au and Ag which are useful reagents for in vivo imaging and therapy. |
