Cysteine-depleted muteins of interleukin-2, their preparation, formulations containing them, and genes, vectors and organisms suitable for use in the preparation of said muteins.

摘要

The invention provides biologically active muteins of human interleukin-2 wherein the cysteine residue normally present at position 125, numbered in accordance with native interleukin-2, has been substitued by a neutral amino acid. Such muteins are incapable of forming an improper intramolecular disulfide bridge and are stable upon storage relative to bacterially derived reduce native interleukin-2.