| 摘要 |
1-Benzoheterocyclyl-1H-imidazole -3-carboxylic acid derivs. of formula (I) and their salts and quat. derivs. and their N-oxides are new. In the formula R1 = H or SH; R2 = H, 1-7C alkyl, 3-7C alkenyl, 3-7C alkynyl, 3-7C cycloalkyl, (1-7C)alkoxy-(1-7C) alkyl or aryl-(1-5C)alkyl; n = 0, 1 or 2; Y = S(O)m-CH2, O-CH2, N(E)-CH2 or N=CH, the heteroatom being linked to the C atom of the benzene ring; m = 0, 1 or 2; E = H, 1-5C alkyl, 1-5C alkanoyl or p-MeC6H4SO2; R3-R6=H, 1-6C alkyl, mono- or di-aryl-(1-5C)alkyl, 1-6C alkoxy, halogen, 3-7C alkenyl 1-5C alkyl or 1-5C alkoxy each substd. with 1-3 halogens or aryl; or R3+R4 = residue of a fused benzene ring opt. substd. by 1 or 2 H, 1-5C alkyl, 1-5C alkoxy, halogen, 1-5C alkyl or 1-5C alkoxy both substd. by 1-3 halogens, NO2, NH2 or NH-CPG; or when R3+R4 are geminally substd. they form a 3-7C spirocyclic C ring; R7, R8 = H, 1-5C alkyl, 1-5C alkoxy, halogen, 1-5C alkyl or 1-5C alkoxy both substd. by 1-3 halogens, CN, NO2 NH2, mono-or di-(1-5C) alkylamino or NH-COG; G = 1-6C alkyl; aryl = Ph opt. substd. by 1-3 halogen, 1-5C alkyl or 1-5C alkoxy. R3-R6 may be present on any C atom of the Y-contg.part of the bicyclic ring, including the CH2 or CH gps. of the (CH2)n, S-CH2, 0-CH2, N(E)-CH2 or N=CH.
|
