发明名称 2-AMINOACYLOXYMETHYL-2-PENEM DERIVATIVES
摘要 Compounds of the formula <IMAGE> in which R1 is lower alkyl substituted by hydroxyl or protected hydroxyl, R2 denotes carboxyl or a functionally modified carboxyl, R0 is azacycloalkyl or a group of the formula -Y-N(R3,R4), in which R3 is hydrogen or lower alkyl, R4 is hydrogen, lower alkyl or acyl and Y is lower alkylene, lower alkylene substituted by phenyl or a radical of the formula -CR5R6- in which R5 represents an organic radical bonded via a carbon atom or, together with R3, lower alkylene optionally substituted by oxo or hydroxyl, and R6 denotes hydrogen or lower alkyl, the pure optical isomers of compounds of the formula (I) and mixtures of these optical isomers, and salts of such compounds have antibiotic properties. The compounds can be prepared by processes known per se.
申请公布号 AU6879787(A) 申请公布日期 1987.08.20
申请号 AU19870068797 申请日期 1987.02.13
申请人 CIBA-GEIGY AG 发明人 MARC LANG
分类号 C07D499/897;A61K31/43;A61P31/04;C07D205/09;C07D499/04;C07D499/06;C07D499/88;C07F9/568 主分类号 C07D499/897
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