| 摘要 |
NEW MATERIAL:An analogue (GHRH-4) of growth hormone-releasing hormone (GHRH) expressed by the formula [Agm represents agmatine or residue of the formula H2N(CH2)4NHC(=NH)NH2]. USE:A remedy and diagnosticum for puerilism or auxetic for an animal. PREPARATION:For example, plural fragments of intermediate for GHRH-A are synthesized by step-wire elongation method of peptide and bonded with each other. First the formula Boc-Ser(Bzl)-OSu (Boc represents t-butoxycarbonyl; Bzl represents benzyl; OSu represents N-hydroxysuccinimide ester) is reacted with Agm.H2SO4, and amino acids are successively bonded according to a peptide sequence. On the other hand, a compound expressed by the formula Boc-Gln-OH is used as a raw material and amino acids are successively bonded therewith according to the peptide sequence to obtain an intermediate. Then these intermediates are bonded to obtain the compound expressed by the formula. |
