Process for preparing optically active fluorine-containing compounds.

摘要

A process for preparing an optically active fluorine-containing compound, which comprises reacting a stereoisomer of a compound which has an ester carbonyl group or a lactam carbonyl group and has a hydroxyl group bonded to an asymmetric carbon atom at beta -position of the carbonyl group, with a fluorinating agent which is a reaction product of hexafluoropropene and diethylamine in an amount of 1 to 5 moles to 1 mole of the stereoisomer by controlling a temperature of the reaction system within a range from -50 DEG to 25 DEG C to substitute the hydroxyl group by fluorine atom; said optically active fluorine-containing compound has a configuration inverse to that of the starting stereoisomer. According to the present invention, the hydroxyl group can be stereoselectively fluorinated at a relatively high temperature.