Serum thymic factor peptide analogs and a process for the preparation thereof.

摘要

Novel peptide analogs of the serum thymic factor are structurally modified, in comparison with the natural substance, both in their N-terminal and C-terminal parts and inside the amino-acid sequence. They correspond to the general formula I
<Chemistry id="chema01" num="0001"><Image id="ia01" he="8" wi="82" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which A is pGlu, Gin, Ala-Lys-Ser, pGlu-Ala-Lys-Ser or Gln-Ala-Lys-Ser, B and C are Gly, Phe, Leu, Ala or a direct bond and R is H, an alkyl with 1 to 6 carbon atoms or a 2-phenylethyl.

Dependently on their chemical structure, the subject thymic factor analogs, possess either agonistic (im- munostimulative) or antagonistic (immunosuppressory) properties.